Triple Hormone Obesity Drug, Cancer Resistance, and Aging's Lipid Clock

Today's briefing covers a landmark New England Journal of Medicine trial of the triple hormone obesity drug retatrutide, real world data on dupilumab for chronic obstructive pulmonary disease, and a Cell study revealing how estrogen helps cancer cells evade antibody therapies. We also look at a cross species aging signature in lipid chemistry, a newly discovered backup pathway against ferroptosis, and how fat cells sense time, diet, and temperature. Plus a quick rundown of six more studies spanning lung cancer screening, gut microbiome research, vitamin D, sleep biology, and heart failure.