Chemo-Free Leukemia Wins, Estrogen's Role in Drug Resistance, and Rethinking Heart Attack Triage

Today's briefing covers a chemotherapy-free regimen that outperforms standard treatment in Philadelphia-positive acute lymphoblastic leukemia, a Cell study showing estrogen drives resistance to antibody-drug conjugates in cancer, and new Cochrane evidence questioning medical cannabis for insomnia. We also look at a smarter way to catch blocked coronary arteries missed by standard ECG criteria, a major review of adult attention deficit hyperactivity disorder, and the shifting treatment landscape for knee osteoarthritis. A quick rundown covers bladder cancer, kidney injury, diet science, obesity drugs, and more.